Wnt signaling: Ig-Norrin the dogma

Hans Clevers

doi:10.1016/j.cub.2004.05.039

Wnt signaling: Ig-Norrin the dogma

Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

29 Citaten (Scopus)

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Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

Originele taal-2	Engels
Pagina's (van-tot)	R436-R437
Tijdschrift	Current Biology
Volume	14
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1016/j.cub.2004.05.039
Status	Gepubliceerd - 8 jun. 2004
Extern gepubliceerd	Ja

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10.1016/j.cub.2004.05.039

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title = "Wnt signaling: Ig-Norrin the dogma",

abstract = "Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.",

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AB - Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

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M3 - Review article

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Wnt signaling: Ig-Norrin the dogma

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