Wnt signaling: Ig-Norrin the dogma

Hans Clevers

doi:10.1016/j.cub.2004.05.039

Wnt signaling: Ig-Norrin the dogma

Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

29 Citaten (Scopus)

Samenvatting

Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

Originele taal-2	Engels
Pagina's (van-tot)	R436-R437
Tijdschrift	Current Biology
Volume	14
Nummer van het tijdschrift	11
DOI's	https://doi.org/10.1016/j.cub.2004.05.039
Status	Gepubliceerd - 8 jun. 2004
Extern gepubliceerd	Ja

Toegang tot document

10.1016/j.cub.2004.05.039

Citeer dit

@article{c4604aa1256d46f3bf05c9835f6b23cd,

title = "Wnt signaling: Ig-Norrin the dogma",

abstract = "Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.",

author = "Hans Clevers",

year = "2004",

month = jun,

day = "8",

doi = "10.1016/j.cub.2004.05.039",

language = "English",

volume = "14",

pages = "R436--R437",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "11",

}

TY - JOUR

T1 - Wnt signaling

T2 - Ig-Norrin the dogma

AU - Clevers, Hans

PY - 2004/6/8

Y1 - 2004/6/8

N2 - Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

AB - Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.

UR - https://www.scopus.com/pages/publications/2642583350

U2 - 10.1016/j.cub.2004.05.039

DO - 10.1016/j.cub.2004.05.039

M3 - Review article

C2 - 15182694

AN - SCOPUS:2642583350

SN - 0960-9822

VL - 14

SP - R436-R437

JO - Current Biology

JF - Current Biology

IS - 11

ER -

Wnt signaling: Ig-Norrin the dogma

Samenvatting

Toegang tot document

Vingerafdruk

Citeer dit