Wnt signaling in the thymus

Frank J.T. Staal, Hans C. Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

74 Citaten (Scopus)


Wnt proteins are secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis in many different tissues and species. Wnt signaling is required for normal thymocyte development, most dramatically at the pro-T-cell stage, although recent reports also indicate a role for Wnt proteins in later stages of thymocyte differentiation. The Wnt cascade induces the interaction of the normally cytoplasmic cofactor β-catenin with the nuclear Tcf and Lef transcription factors. Active Wnt signaling is an absolute requirement for T-cell development, as demonstrated by the complete block in thymocyte development observed in the absence of Tcf1 and Lef1, or in the presence of extracellular Wnt inhibitors.

Originele taal-2Engels
Pagina's (van-tot)204-208
Aantal pagina's5
TijdschriftCurrent Opinion in Immunology
Nummer van het tijdschrift2
StatusGepubliceerd - apr. 2003
Extern gepubliceerdJa


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