WNT signalling and haematopoiesis: A WNT-WNT situation

Frank J.T. Staal; Hans C. Clevers

doi:10.1038/nri1529

WNT signalling and haematopoiesis: A WNT-WNT situation

Frank J.T. Staal, Hans C. Clevers

Onderzoeksoutput: Bijdrage aan tijdschrift › Artikel recenseren › peer review

289 Citaten (Scopus)

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The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

Originele taal-2	Engels
Pagina's (van-tot)	21-30
Aantal pagina's	10
Tijdschrift	Nature Reviews Immunology
Volume	5
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/nri1529
Status	Gepubliceerd - jan. 2005
Extern gepubliceerd	Ja

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abstract = "The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.",

author = "Staal, {Frank J.T.} and Clevers, {Hans C.}",

note = "Funding Information: We thank C. E. van der Linden for careful reading of the manuscript. F.J.T.S. is supported by grants from NWO (The Netherlands), the Fifth and Sixth Framework Programmes (European Union) and the Bekales Foundation (Belgium).",

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AB - The evolutionarily conserved WNT-signalling pathway has pivotal roles during the development of many organ systems, and dysregulated WNT signalling is a key factor in the initiation of various tumours. Recent studies have implicated a role for WNT signal transduction at several stages of lymphocyte development and in the self-renewal of haematopoietic stem cells. Here, we outline new insights into the WNT-signalling pathway, review its role in the self-renewal of haematopoietic stem cells and in the development of T and B cells, and discuss controversies and future developments with regard to WNT signalling in the thymus.

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WNT signalling and haematopoiesis: A WNT-WNT situation

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