Wnt signalling in stem cells and cancer

Tannishtha Reya, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

3126 Citaten (Scopus)

Samenvatting

The canonical Wnt cascade has emerged as a critical regulator of stem cells, in many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.

Originele taal-2Engels
Pagina's (van-tot)843-850
Aantal pagina's8
TijdschriftNature
Volume434
Nummer van het tijdschrift7035
DOI's
StatusGepubliceerd - 14 apr. 2005
Extern gepubliceerdJa

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