Wnt, stem cells and cancer in the intestine

Daniel Pinto, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

145 Citaten (Scopus)


The intestinal epithelium is a self-renewing tissue which represents a unique model for studying interconnected cellular processes such as proliferation, differentiation, cell migration and carcinogenesis. Although the stem cells of the intestine have not yet been physically characterized or isolated, data over the past decade have strongly implicated the Wnt/β-catenin signalling pathway in their maintenance and progression to cancer. This review will (i) describe the distinctive features of the intestinal epithelium in relation to stem-cell function, (ii) illustrate the major genetic alterations that can lead to cancer, and (iii) show how Wnt/β-catenin signalling controls homoeostasis in this tissue.

Originele taal-2Engels
Pagina's (van-tot)185-196
Aantal pagina's12
TijdschriftBiology of the Cell
Nummer van het tijdschrift3
StatusGepubliceerd - mrt. 2005
Extern gepubliceerdJa


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