@article{4aeb95069456478080876bc45973518c,
title = "Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease",
abstract = "Nucleotide excision repair, which is defective in xeroderma pigmentosum (XP), involves incision of a DNA strand on each side of a lesion. We isolated a human gene homologous to yeast Rad1 and found that it corrects the repair defects of XP group F as well as rodent groups 4 and 11. Causative mutations and strongly reduced levels of encoded protein were identified in XP-F patients. The XPF protein was purified from mammalian cells in a tight complex with ERCC1. This complex is a structure-specific endonuclease responsible for the 5' incision during repair. These results demonstrate that the XPF, ERCC4, and ERCC11 genes are equivalent, complete the isolation of the XP genes that form the core nucleotide excision repair system, and solve the catalytic function of the XPF-containing complex.",
author = "Sijbers, {Anneke M.} and {De Laat}, {Wouter L.} and Ariza, {Rafael R.} and Maureen Biggerstaff and Wei, {Ying Fei} and Moggs, {Jonathan G.} and Carter, {Kenneth C.} and Shell, {Brenda K.} and Elizabeth Evans and {De Jong}, {Mariska C.} and Suzanne Rademakers and {De Rooij}, Johan and Jaspers, {Nicolaas G.J.} and Hoeijmakers, {Jan H.J.} and Wood, {Richard D.}",
note = "Funding Information: Correspondence should be addressed to R. D. W. We thank the members of our laboratories for advice and reagents; A. A. Davies, R. Sowdhamini, W. Vermeulen, and T. Yagi for discussions; and E. C. Friedberg for the Rad1–Rad10 proteins. We thank A. J. van Vuuren, A. de Klein, R. van Os, H. Odijk, and J. de Wit for help with the experiments. This work was supported by the Imperial Cancer Research Fund, the Human Frontiers of Science Programme, the Dutch Scientific Organisation (NWO, Foundation for Chemical Research), and the European Community Human Capital and Mobility Programme. ",
year = "1996",
month = sep,
day = "6",
doi = "10.1016/S0092-8674(00)80155-5",
language = "English",
volume = "86",
pages = "811--822",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "5",
}