You Wnt some, you lose some: Oncogenes in the Wnt signaling pathway

Johan H. Van Es, Nick Barker, Hans Clevers

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel recenserenpeer review

211 Citaten (Scopus)


The highly regulated Wnt signaling cascade plays a decisive role during embryonic patterning and cell-fate determination. The inappropriate expression of Wnt target genes, resulting from deregulation of this pathway, is also implicated in tumorigenesis. Thus, regulation of this pathway is of paramount importance. The Wnt signals are extracellularly regulated by a diverse group of antagonists, cofactors and coreceptors. In the cytoplasm, β-catenin, a key effector of the Wnt signaling cascade, is highly regulated by a large and fascinating complex of proteins. In the nucleus, activation of target genes is regulated by a complex interplay of activators, repressors and other proteins. Recently, new factors in this pathway have been identified and the interplay and mechanisms of action of key players have been better characterized. Collectively, this represents an important step forward in our understanding of the role of Wnt signaling in development and oncogenesis.

Originele taal-2Engels
Pagina's (van-tot)28-33
Aantal pagina's6
TijdschriftCurrent Opinion in Genetics and Development
Nummer van het tijdschrift1
StatusGepubliceerd - feb. 2003
Extern gepubliceerdJa


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